|
|
Study of the effect of novel antiretroviral drugs on carnitine transport in the placenta
Marková, Eliška ; Čečková, Martina (advisor) ; Červený, Lukáš (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Eliška Marková Suprevisor: doc. PharmDr. Martina Čečková, Ph.D. Title of diploma thesis: Study of the effect of novel antiretroviral drugs on carnitine transport in the placenta Nowadays, the antiretroviral treatment of HIV-positive pregnant women is the standard approach for restriction of transmission of HIV infection from mother to the fetus. In spite of necessity of this pharmacotherapy, it is important to know its safety and risks. For the correct fetal development and function of placenta it is (besides others) essential to ensure the optimal supply of L-carnitine, the key factor for oxidation of fatty acids from mother's blood to the placenta and fetal blood circulation. The deficiency of L-carnitine generally leads to significant metabolic changes in the cells and in it usually demonstrated with cardiomyopathies and myopaties. Published studies indicate higher incidence of cardiovascular diseases and cardiomyopathies in children born to mothers treated with antiretroviral therapy during pregnancy. Optimal transport of carnitine into the placental cells, is ensured due to the presence of functional transport protein OCTN2 in the apical membrane of trophoblast. The aim of this study was...
|
|
|
Study of the effect of novel antiretroviral drugs on carnitine transport in the placenta
Marková, Eliška ; Čečková, Martina (advisor) ; Červený, Lukáš (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Eliška Marková Suprevisor: doc. PharmDr. Martina Čečková, Ph.D. Title of diploma thesis: Study of the effect of novel antiretroviral drugs on carnitine transport in the placenta Nowadays, the antiretroviral treatment of HIV-positive pregnant women is the standard approach for restriction of transmission of HIV infection from mother to the fetus. In spite of necessity of this pharmacotherapy, it is important to know its safety and risks. For the correct fetal development and function of placenta it is (besides others) essential to ensure the optimal supply of L-carnitine, the key factor for oxidation of fatty acids from mother's blood to the placenta and fetal blood circulation. The deficiency of L-carnitine generally leads to significant metabolic changes in the cells and in it usually demonstrated with cardiomyopathies and myopaties. Published studies indicate higher incidence of cardiovascular diseases and cardiomyopathies in children born to mothers treated with antiretroviral therapy during pregnancy. Optimal transport of carnitine into the placental cells, is ensured due to the presence of functional transport protein OCTN2 in the apical membrane of trophoblast. The aim of this study was...
|
|
|
Study of the effect of novel antiretroviral drugs on carnitine transport in the placenta
Marková, Eliška ; Čečková, Martina (advisor) ; Červený, Lukáš (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Eliška Marková Suprevisor: doc. PharmDr. Martina Čečková, Ph.D. Title of diploma thesis: Study of the effect of novel antiretroviral drugs on carnitine transport in the placenta Nowadays, the antiretroviral treatment of HIV-positive pregnant women is the standard approach for restriction of transmission of HIV infection from mother to the fetus. In spite of necessity of this pharmacotherapy, it is important to know its safety and risks. For the correct fetal development and function of placenta it is (besides others) essential to ensure the optimal supply of L-carnitine, the key factor for oxidation of fatty acids from mother's blood to the placenta and fetal blood circulation. The deficiency of L-carnitine generally leads to significant metabolic changes in the cells and in it usually demonstrated with cardiomyopathies and myopaties. Published studies indicate higher incidence of cardiovascular diseases and cardiomyopathies in children born to mothers treated with antiretroviral therapy during pregnancy. Optimal transport of carnitine into the placental cells, is ensured due to the presence of functional transport protein OCTN2 in the apical membrane of trophoblast. The aim of this study was...
|
|
|
Creatine and Carnitine Use in Sport
Vodičková, Věra ; Vilikus, Zdeněk (advisor) ; Boudová, Lea (referee)
5 Abstrakt Kreatin je z 95 % obsažen v kosterních svalech, kde je z 65 % fosforylován na kreatinfosfát. Denní potřeba 2 g je kryta příjmem z potravy a biosyntézou. Systém kreatin - kreatinfosfát slouží ve svalech pro rychlou regeneraci ATP, pro vyrovnávání pH a podílí se na růstu svalové hmoty. Základní a prokazatelně účinnou formou suplementů je kreatin monohydrát, jiné preparáty nejsou účinnější. Podávání kreatinu je bezpečné, potvrzeným nežádoucím účinkem je pouze nárůst hmotnosti a trávící obtíže. Je prokazatelně efektivní pro zvýšení výkonnosti, zejména při opakované krátkodobé intenzivní zátěži a v silových disciplínách. Nejúčinnějším postupem podávání je využívání tzv. plnící fáze, následované fází udržovací a pauzou, které se v cyklech opakují. Účinnost zvyšuje současné podání sacharidů. Nárůst výkonnosti koreluje s velikostí nárůstu obsahu kreatinu ve svalech, která závisí na velikosti jeho zásob před zahájením suplementace. Karnitin se vyskytuje ve dvou optických formách, ovšem pouze L-forma je metabolicky účinná a bezpečná. Jeho hlavní funkcí je přenos aktivovaných mastných kyselin do matrix mitochondrie, kde probíhá jejich β-oxidace. Denní potřeba karnitinu je z 25 % kryta biosyntézou, zbylých 75 % ...
|
|
| |
|
| |
|
| |
guest ::
